Chelsea and Arsenal meet at Stamford Bridge after both teams dropped points in Matchweek 23.
The fourth-placed Blues lost at Newcastle United which means that, following their draw against Sheffield United, Arsenal can move seven points behind their London rivals with a win on Tuesday.
Chelsea full-back Reece James (knee), who was forced off against Newcastle United, is in contention for Tuesday's match, although Frank Lampard says the decision on whether to play him will be a "tight call".
Marcos Alonso (back) has returned to fitness and will be in the squad.
Arsenal will be without Sead Kolasinac (thigh) and Reiss Nelson (hamstring) while Pierre-Emerick Aubameyang serves the second of his three-match suspension.
Defender Sokratis (illness) is being assessed. Kieran Tierney (shoulder) and Calum Chambers (knee) are long-term absentees.
Chelsea are looking to complete the Premier League double against Arsenal for the fifth time, having done so in 2005/06, 2009/10, 2012/13 and 2015/16. Only Liverpool and Man Utd have done this against the Gunners on five occasions.
Frank Lampard is looking to become the first English Chelsea manager to do the league double against Arsenal since Dave Sexton in 1969/70.
No team has won more Premier League away matches at Stamford Bridge than Arsenal's seven.
Only Norwich City, with 6,245, have given more Premier League minutes to players aged 21 or younger this season than Chelsea's 5,736 and Arsenal's 4,091.
Referee: Stuart Attwell. Assistants: Ian Hussin, Richard West. Fourth official: David Coote. VAR: Paul Tierney. Assistant VAR: Constantine Hatzidakis.