Both Chelsea and Southampton are looking to record back-to-back victories.
Chelsea, sitting fourth on 32 points, aim to extend their Premier League record to 15 Boxing Day matches without defeat.
Southampton moved out of the bottom three with victory at Aston Villa last time out and are seeking a fourth win from six matches.
Cesar Azpilicueta will be assessed by the Chelsea medical team after sustaining a knock at Spurs. The Blues otherwise report no new fresh injury concerns.
Southampton striker Shane Long is a major doubt for the festive fixtures with a knee problem
However, Kevin Danso (illness) and Sofiane Boufal (toe) are set to return. Moussa Djenepo (hamstring) and Yan Valery (virus) are still unavailable.
Chelsea have won seven of their last eight Premier League matches against Southampton, since a 3-1 home loss in October 2015.
Chelsea and Southampton have met four times on Boxing Day in the Premier League, most famously 20 years ago when Chelsea became the first Premier League side to name a starting XI with no British players in a 2-1 win at the Dell.
Referee: Jonathan Moss. Assistants: Marc Perry, Eddie Smart. Fourth official: Gavin Ward. VAR: Simon Hooper. Assistant VAR: Derek Eaton.