The Leicester City striker was the second most-bought player for Gameweek 10, earning over 275,000 transfers in.
And he rewarded his new owners with a 20-point return in Friday night's 9-0 win, matching the highest individual haul in 2019/20 FPL.
He now has 74 points, two more than his nearest challenger, Kevin De Bruyne (£10.2m).
Vardy was among four Leicester players to deliver double-digit hauls at St Mary’s Stadium.
Meanwhile, left-back Ben Chilwell (£5.5m) added a goal and two assists to his clean sheet to tally 19 points.
Encouragingly, Leicester’s upcoming schedule raises their prospects of further big hauls.
According to the Fixture Difficulty Ratings (FDR), six of their next seven opponents score just two.
Vardy, Chilwell, Perez and Tielemans are currently the four most transferred-in players ahead of Gameweek 11.
The US international scored a hat-trick and picked up the maximum bonus to also serve up 20 points.
His team-mate Willian (£7.0m) produced his own season-high haul of 12 points, thanks to a goal and assist at Turf Moor.
Meanwhile, the most-captained player of Gameweek 10, Raheem Sterling (£12.1m), returned his first double-digit haul since the opening weekend.
Brighton and Hove Albion's forwards continue to provide strong value too.
Maupay, who was highlighted by The Scout as one to watch for Gameweek 10, has now scored in three successive home matches. He hosts Norwich City in Gameweek 11.
Ben Foster (£4.8m) was again the standout performer for the Hornets.
The goalkeeper has claimed 10 points in both of his last two matches at Vicarage Road.