Crystal Palace's defensive woes mean Manchester City’s Sergio Aguero (£13.2m) inevitably leads a cast of captaincy contenders for Gameweek 12, but there is competition for managers seeking differential.
The most popular forward in Fantasy Premier League, Aguero played only 45 minutes of Argentina's two recent internationals ahead of Saturday's trip to Selhurst Park.
He has scored twice in three of four away appearances under Pep Guardiola, earning 44 of his 61 points on the road.
Aguero also faces a Palace backline who have yet to register a single clean sheet, with eight goals conceded in five home matches.
A home meeting with Swansea City boosts the prospects of Romelu Lukaku (£9.9m), who provides the major captaincy rival to Aguero.
The Everton striker, who plundered two goals and an assist in Belgium's 8-1 win over Estonia in midweek, has produced two double-figure hauls in his last three Goodison Park appearances.
Swansea arrive on Merseyside having conceded nine goals in four matches under new manager Bob Bradley. No side have allowed more big chances over the last four Gameweeks.
Eden Hazard (£10.1m) and Diego Costa (£10.5m) have shaken off knocks in time for Chelsea's trip to Middlesbrough on Sunday.
Subject to more transfers in than any player in the Gameweek, Hazard has racked up five goals and two assists in the last four fixtures, but Costa has been more prolific on the road.
The Spain forward has scored five of his nine goals on his travels, whereas only one of Hazard's seven strikes has come away from Stamford Bridge.
The pair will be tested against an organised Middlesbrough defence who have conceded only once in the last three Gameweeks.
Sunderland's Jermain Defoe (£7.4m) sits level with Aguero on 61 points ahead of a home match with Hull City.
The striker has played a part in seven of the Black Cats' goals, scoring six and setting up another, and has earned more transfers in than any forward this Gameweek.
He faces a defence who have let in more goals (24) and shots inside the box (131) than any other side this season.
Harry Kane (£10.7m) returned to action with a converted penalty in the Gameweek 11 north London derby.
Owned by 5.5%, the Tottenham Hotspur frontman has scored in each of his last three Premier League appearances ahead of a home encounter with West Ham United.
Liverpool’s in-form pair Philippe Coutinho (£8.7m) and Roberto Firmino (£8.7m) offer decent armband alternatives ahead of tomorrow's trip to St Mary's Stadium.
Coutinho has produced four sets of double-figure returns to Firmino's three as they prepare to face a Southampton defence who have not kept a clean sheet in their last four Gameweeks.
However, managers will be fretting over news that Coutinho has had scans on a hamstring problem after a long-haul back from South America and remains a doubt for the weekend.
