Toby Alderweireld (knee), Erik Lamela (hip) and Ben Davies (ankle) have been ruled out for Tottenham Hotspur and Dele Alli (knee) is doubtful.
Danny Rose, Christian Eriksen, Mousa Dembele and Vincent Janssen have recovered from knocks and are available along with Moussa Sissoko, who has served out a suspension.
Winston Reid and James Collins are both back in training for West Ham United, who could have Diafra Sakho back in contention.
Mark Noble is suspended and Gokhan Tore, Sam Byram (both thigh), Arthur Masuaku and Andy Carroll (both knee) are still injured.
Did you know?
Although they defeated West Ham United 4-1 at home last November, Tottenham Hotspur have won only one of their last four meetings with them at White Hart Lane in all competitions (D1 L2).
West Ham, although, have won only once in their last 14 league visits to Spurs (L8 D5).
Spurs are the only unbeaten Premier League side this season (W5 D6 L0). Only twice before in the top flight have they managed to avoid defeat in their opening 12 matches (1959/60 and 1960/61).
Harry Kane, who has 15 goals in his last 15 London PL derbies, has scored three times in two previous home PL outings against West Ham.
What the managers say
Mauricio Pochettino: "Dele is recovering well from his injury. We need to assess him tomorrow (Friday) but we are very happy with how he is recovering."
See: Pochettino on Kane and Eriksen | Alderweireld fitness update
Slaven Bilic: "I know we have solutions within our squad. We have players who were absent who are now coming back. They're like new signings for us."
See: Bilic press conference in full | Cresswell: I couldn't be happier
