Two of the top three teams meet at Anfield as Brendan Rodgers returns to face his former club.
Liverpool are aiming for a 17th successive Premier League victory, while Leicester City are seeking a fifth win in six matches.
Team news
Liverpool's Joel Matip and Xherdan Shaqiri will miss Saturday's match through injury but goalkeeper Alisson is back in training and is being considered for a return.
Did you know?
Liverpool are unbeaten in 43 home league matches, the longest current run in the top five European leagues and the club’s second-longest in top-flight history. Their previous best sequence of 63 was ended by Leicester in December 1980.
Leicester can achieve back-to-back unbeaten matches against Liverpool for the first time since a run of seven between December 1996 and May 2000.
Sadio Mane can score his 50th Premier League goal for Liverpool in his 100th appearance for the club, becoming the 10th player to reach a half-century in the competition for the Reds, more than any other side.
Jamie Vardy has scored seven PL goals against Liverpool. Only Andrew Cole and Thierry Henry, with 11 and eight respectively, have scored more against them.
Match officials
Referee: Chris Kavanagh. Assistants: Daniel Cook, Sian Massey-Ellis. Fourth official: Mike Dean. VAR: Anthony Taylor. Assistant VAR: Adam Nunn.