Manchester United, who lie eighth, are looking to bounce back from their defeat at West Ham United and secure a third victory of the season.
Arsenal, who are four places and three points ahead of their hosts, are aiming for a second consecutive win after coming from behind with 10 men to beat Aston Villa on Sunday.
Team news
Paul Pogba (ankle) and Marcus Rashford (groin) are doubts for Manchester United who are without injured players Anthony Martial, Phil Jones, Eric Bailly, Tim Fosu-Mensah, Diogo Dalot and Angel Gomes.
Luke Shaw is fast-recovering from a thigh problem, though, and has a chance of featuring.
Arsenal could play Hector Bellerin and Kieran Tierney for the first time in the Premier League after the full-backs returned from long-term injuries in the Carabao Cup.
Dinos Mavropanos is available having built up his fitness but Alexandre Lacazette (ankle) has been joined on the sidelines by Emile Smith Rowe (head).
Did you know?
Man Utd are unbeaten in their last 12 Premier League home matches against Arsenal, (W8 D4 L0) since a 1-0 defeat in September 2006.
Arsenal are looking to register consecutive PL victories over Man Utd for the first time since winning both fixtures in 2006/07.
Jesse Lingard has scored four goals for United against Arsenal in all competitions, more than he has against any other side.
Pierre-Emerick Aubameyang has scored 13 goals in his last 13 Premier League starts, and his tally of six strikes is the most by an Arsenal player in the first six matches of the season since Emmanuel Adebayor in 2007/08 (also six).
Match officials
Referee: Kevin Friend. Assistants: Scott Ledger, Richard West. Fourth official: Chris Kavanagh. VAR: Mike Dean. Assistant VAR: Stephen Child.
