Old Trafford has been the scene of 11 last-minute winners in the Premier League but all had been for Manchester United and none for the opposition.
The Palace left-back therefore became the first visiting player to score a winning goal in the 90th minute or later against Man Utd in Premier League history.
Indeed, only one player has scored a winner that late against Man Utd in the Premier League. That was Thierry Henry, whose header in the third minute of stoppage time gave Arsenal a 2-1 win at Emirates Stadium in January 2007.
Van Aanholt's goal also earned Palace a first ever Premier League victory over United at the 21st attempt.