The Portuguese won eight of his 12 Premier League encounters with the Reds during his two previous spells as Chelsea manager, drawing two and losing twice. Another win would put Man Utd level on points with their fourth-placed opponents.
But Liverpool have scored more goals than any other Premier League side since Jurgen Klopp took over as manager in October 2015 (73), and Mourinho says an attacking approach is the best way to nullify their threat.
"We will try to win, that is for sure," he told manutd.com. "When they have the ball we have to defend and when we have the ball we have to attack.
"We want to stop them scoring and the best way to do this is with 11 men and to score we want to be dominant, have the ball and this is what we are doing."