Third-placed Tottenham Hotspur are seeking to maintain their winning start at their new stadium and close in on securing a top-four finish.
West Ham United are targeting a first victory in five matches.
Spurs are again without Harry Kane (ankle), Serge Aurier, Erik Lamela (both hamstring), Moussa Sissoko and Harry Winks (both groin).
West Ham trio Chicharito, Manuel Lanzini and Aaron Cresswell have returned to training this week, while Jack Wilshere has shown no ill-effects after making his first appearance for three and a half months last weekend.
Samir Nasri (calf) is close to his own comeback but is not yet ready. Andy Carroll (ankle), Andriy Yarmolenko (Achilles), Winston Reid and Carlos Sanchez (both knee) remain on the sidelines.
Spurs can complete their first league double over West Ham since 2012/13, and can also beat the Irons for a third time in a season in all competitions for the first time ever. This is the 12th campaign where these sides have met at least three times.
Only Chelsea, with 22 points, have earned more points in Premier League London derbies than Spurs this season, with 19. Mauricio Pochettino’s side have won three of their four at home, drawing the other.
After a run of five consecutive PL home clean sheets against West Ham, Spurs have conceded in their last six home matches against them.
West Ham are looking for their first PL away win against a current top-six side in 21 attempts (D6 L14). They have lost their last six such matches by an aggregate score of 16-3.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Jonathan Moss