Ninth-placed Everton are seeking a fourth victory in five matches, while Manchester United are aiming for a third win in four fixtures and a return to the top four.
Andre Gomes will miss Everton's next three matches after accepting an FA charge of violent conduct following an incident in the 2-0 defeat at Fulham.
Centre-back Yerry Mina (thigh) is the Toffees' only absentee through injury.
Ole Gunnar Solskjaer could call upon Alexis Sanchez and Nemanja Matic, who have been training this week after recovering from injuries.
Ander Herrera has also rejoined the group and Eric Bailly (head) is closing in on his own return, although Sunday's match looks to have come too early for the pair.
Luke Shaw is unavailable again as he completes a two-match ban.
Everton’s only previous league win, and Man Utd’s only previous league defeat, on Easter Sunday came in this exact fixture in 2013/14, when the Toffees triumphed 2-0.
Everton lost 36 Premier League matches against Man Utd, more than any side has against another in the history of the competition.
United have lost their last two PL away matches. They have not lost three in a row on the road since January 1996.
Anthony Martial has scored in his last three PL matches against Everton. The last United player to score in four straight matches against a single opponent was Wayne Rooney v Hull City in November 2014.
Referee: Paul Tierney
Assistants: Constantine Hatzidakis, Eddie Smart
Fourth official: Lee Mason
