Manchester United are targeting a seventh successive Premier League victory, while Burnley are aiming for a fourth win in five top-flight matches.
Ole Gunnar Solskjaer may have Chris Smalling (ankle) available again but Marcos Rojo (knock) is doubtful and Marouane Felllaini (calf) remains out.
Burnley's Johann Berg Gudmundsson (thigh) and Phil Bardsley (muscular) are in contention to play, Robbie Brady (groin) is facing a late fitness test but Aaron Lennon (knee) is out.
Man Utd have the highest PL win-rate for Tuesday fixtures, with 62.5 per cent, but Burnley manager Sean Dyche is undefeated in his five PL matches played on a Tuesday.
Burnley have won 45 per cent of their 22 PL points in their last four matches, while Man Utd have won 41 per cent of their 44 points in their six outings under Ole Gunnar Solskjaer.
Solskjaer could become the first-ever manager to win his first seven PL matches in charge of a club. He is currently level with Carlo Ancelotti (Chelsea) and Pep Guardiola (Manchester City) on six.
Marcus Rashford can become the third-youngest player to score in five successive PL appearances, behind Nicolas Anelka (1998) and Jose Antonio Reyes (2004).
Referee: Jonathan Moss
Assistants: Marc Perry, Harry Lennard
Fourth official: Martin Atkinson