Manchester City will be hoping to close the seven-point gap on unbeaten leaders Liverpool.
Man City midfielder Kevin De Bruyne (muscle) is in contention to return to action.
Benjamin Mendy (knee) and Claudio Bravo (Achilles) are long-term absentees. Fabian Delph is suspended.
Liverpool vice-captain James Milner (hamstring) could return.
Sergio Aguero has scored in all six home league appearances v Liverpool, the best 100 per cent rate of home matches scored in by a player against any opponent in Premier League history.
Man City have won only one of their last 11 meetings with Liverpool in all competitions, although that was a 5-0 victory at the Etihad in the Premier League last season.
Liverpool have claimed victory in only one of their last nine league visits to the Etihad Stadium, winning 4-1 in Jurgen Klopp's first away fixture against them as Reds manager.
No team have failed to win an English top-flight title with at least a seven-point lead coming into the new year before.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Martin Atkinson