Arsenal are aiming to return to winning ways after their draw at Old Trafford, while Huddersfield Town are seeking to avoid a third successive defeat.
Team news
Arsenal defender Rob Holding has been ruled out for between six to nine months after rupturing the anterior cruciate ligament in his knee.
Aaron Ramsey (ankle), Mesut Ozil (back) and Nacho Monreal (hamstring) will be assessed before the match, as will Laurent Koscielny, who played in the midweek Checkatrade Trophy tie without complications.
Huddersfield Town will be without suspended duo Steve Mounie and Philip Billing but Terence Kongolo is available after coming off against AFC Bournemouth.
Abdelhamid Sabiri will be out for around two months with a broken collarbone while Chris Lowe could return.
Did you know?
Arsenal won both Premier League meetings with Huddersfield Town last season (5-0 at home, 1-0 away) and are unbeaten in 10 matches against them in all competitions.
The Gunners have won 16 of their last 17 PL matches at 3pm on a Saturday, including each of the last nine. The only exception in that run was a 0-0 draw against Middlesbrough in October 2016.
Although Huddersfield have only won one of their last 10 PL away matches and were defeated at AFC Bournemouth in their last outing, they’ve not lost back-to-back fixtures on the road in the competition since March.
Huddersfield have lost eight of their last nine top-flight matches against Arsenal, failing to score in each defeat.
Referee: Paul Tierney
Assistants: Simon Beck, Mick McDonough
Fourth official: Stuart Attwell
