Arsenal are aiming to extend their unbeaten run to 13 Premier League matches and build on their derby triumph over Tottenham Hotspur, while Manchester United are looking for a first win in four top-flight outings.
Team news
Ashley Young is suspended for the visit of the Gunners and could be replaced by Diogo Dalot who made his PL debut as a substitute against Southampton on Saturday.
Alexis Sanchez and Victor Lindelof (both thigh) are out, while Luke Shaw (knock) is to be assessed.
There are also defensive doubts over Phil Jones (knock), Chris Smalling (ankle), Eric Bailly (back) and Antonio Valencia (knock).
For Arsenal, midfielder Granit Xhaka is suspended, while Mesut Ozil (back), Nacho Monreal (hamstring) and Laurent Koscielny (Achilles) are being assessed.
Danny Welbeck (ankle) and Dinos Mavropanos (groin) are out.
Did you know?
Man Utd are unbeaten in their last 11 PL home matches against Arsenal, since a 1-0 loss in September 2006.
United, who won both of their PL meetings with Arsenal last season, can now secure a third consecutive victory over them for the first time since November 2012.
This is the first time United have hosted Arsenal in a midweek PL match since 8 May 2002, when the Gunners won 1-0 to clinch the title thanks to a Sylvain Wiltord strike.
Arsenal have lost their last three midweek PL matches played on a Tuesday, Wednesday or Thursday and conceded three goals in each defeat against Swansea City, Manchester City and Leicester City last season.
Referee: Andre Marriner
Assistants: Scott Ledger, Simon Long
Fourth official: Chris Kavanagh
