Arsenal are aiming to extend an 11-match unbeaten run in the Premier League, while Tottenham Hotspur are looking for an eighth victory from nine top-flight fixtures.
Team news
Arsenal will monitor the fitness of Alexandre Lacazette (groin) after he missed the win at AFC Bournemouth.
Nacho Monreal (hamstring), Konstantinos Mavropanos (groin) and Danny Welbeck (ankle) are all out.
Erik Lamela is being assessed after sustaining a thigh injury in the UEFA Champions League win against Inter Milan on Wednesday.
Right-back Kieran Trippier (groin), midfielders Victor Wanyama (knee) and Mousa Dembele (ankle) and centre-back Davinson Sanchez (hamstring) are all out.
Did you know?
Arsenal and Spurs have both found the net in 34 PL north London derbies, more than in any other fixture in the competition.
Unai Emery can become only the third of the last 10 Arsenal managers, including caretakers, to win his first north London derby in the league, after Don Howe, in 1983, and Arsene Wenger, in 1996.
Spurs have won their last seven PL London derbies and can equal their longest derby winning run in the top flight, eight victories between October 1950 and August 1951.
Mauricio Pochettino has managed five away league matches against Arsenal without winning, the worst run he has had against any opponent, in England or Spain.
Referee: Mike Dean
Assistants: Darren Cann, Dan Robathan
Fourth official: Andre Marriner
