History suggests they have the right man in the dugout to do so when they face Leicester City on Friday 10 August.
Not only are United the club with the best Matchweek 1 record in Premier League history, but in Jose Mourinho they also have the managerial equivalent.
Special Matchday 1
Mourinho is unbeaten in nine opening-weekend matches.
The Portuguese has won eight times and drawn once during his time at United and former club Chelsea.
It gives him an average of 2.78 points per fixture in Matchweek 1 and a win percentage of 88.89 per cent.
Both figures are the best of the 38 PL managers, past and present, who have taken charge of at least five opening-weekend fixtures.
Of other managers who will be in charge on the opening weekend, Manuel Pellegrini boasts the joint-best record.
While he has overseen only three Matchweek 1 fixtures, the Chilean, now at West Ham, won all of them with Man City.
Best managers in Matchweek 1*
*Minimum nine matches in charge on opening weekend
Also in this series
Part 1: The impossible job: Compiling the fixture list
Part 2: How the Premier League fixture list is compiled
Part 3: Can 2018/19 live up to last season's opening salvo?
Part 4: Arsenal the place for goals on opening day
Part 5: Who can match Ravanelli's dream debut?
Part 6: Can debutant managers start with a bang?
Part 7: Man Utd kings of the opening weekend
Part 8: Aguero eyes record for opening weekends