Manchester United remain without Romelu Lukaku (ankle) and Marouane Fellaini (muscular) and manager Jose Mourinho has confirmed he will make a number of changes.
David De Gea will be rested having already won the 2017/18 Golden Glove and will be replaced by Sergio Romero. Michael Carrick will captain the side in his final match before retirement.
Marcus Rashford, Anthony Martial, Juan Mata, Daley Blind and Eric Bailly are also set to play.
Nathaniel Chalobah (knee) has a chance of featuring for the first time in eight months for Watford.
Kiko Femenia, Miguel Britos and Andre Carrillo missed training on Friday and are doubtful, while Etienne Capoue (personal reasons) and Stefano Okaka (thigh) have been ruled out.
Did you know?
Manchester United have won 13 of their last 14 meetings with Watford in all competitions, losing only at Vicarage Road in September 2016.
The Red Devils have won more final fixtures in a Premier League campaign than any other side, with 17. They have only finished with a loss twice, against Tottenham Hotspur in 2001 and West Ham United in 2007.
This will be the 500th Premier League match at Old Trafford. There have been more goals scored there than at any other in the competition (1,406).
Troy Deeney has scored three PL goals against Man Utd, all from the penalty spot. Only Steven Gerrard, with four, has scored more spot-kicks against the Red Devils in the competition.
Club previews
Man Utd: Mourinho explains team rotation
Watford: Gracia considering two up front
Referee: Lee Mason
Assistants: Matthew Wilkes, Mick McDonough
Fourth official: Neil Swarbrick
