Manchester United have a fully-fit squad with the exception of goalkeeper Sergio Romero (knee).
Antonio Valencia is expected to be fine after being forced off in the FA Cup semi-final win over Tottenham Hotspur with a muscular injury.
Arsenal midfielder Henrikh Mkhitaryan (knee) is available to play against his former club.
Mohammed Elneny (ankle) remains out but otherwise manager Arsene Wenger has a fully-fit squad.
Did you know?
Manchester United are unbeaten in 10 home league matches against Arsenal (W7 D3), their longest run since a 17-match streak in March 1961.
United's Alexis Sanchez could become the first player to score both for and against the same team in the same Premier League season since Wilfried Bony, for and against Swansea and Man City in 2014/15.
Arsenal have not beaten Man Utd in a match in April since 1978 (D4 L6).
Danny Welbeck has scored in both his visits to Old Trafford for Arsenal in all competitions. No Arsenal player has scored at Man Utd more times under Arsene Wenger, with Emmanuel Adebayor and Sylvain Wiltord also netting two.
Referee: Kevin Friend
Assistants: Simon Bennett, Eddie Smart
Fourth official: Michael Oliver