Tottenham Hotspur's Danny Rose has been ruled out with a minor calf problem but is expected to be available for Tuesday's trip to Brighton & Hove Albion.
Harry Winks (ankle) and Kyle Walker-Peters (hamstring) continue their rehabilitation.
Manchester City striker Sergio Aguero (knee) is injured and Fernandinho starts a two-match ban after his 10th booking of the season.
John Stones (adductor) is out and Benjamin Mendy (knee) is a long-term absentee.
Did you know?
Tottenham Hotspur have only lost one of their last five Premier League meetings with Manchester City, and have won the last two home matches.
Spurs are unbeaten in their last 14 PL matches (W11 D3), their joint-best run in the competition. They last had a longer unbeaten sequence in the top flight between January and August 1967, with 20 matches.
Manchester City could become only the fourth club to win away against Arsenal, Chelsea and Spurs in the same PL campaign, after Coventry City in 1993/94, Charlton Athletic in 2001/02 and Blackburn Rovers in 2002/03.
Only Alan Shearer (14), Wayne Rooney and Jimmy Floyd Hasselbaink (both 11) have scored more PL goals against Spurs than Sergio Aguero's 10.
Club previews
Spurs: Pochettino: I'm always positive
Man City: Guardiola: I don't know when Aguero will return
Referee: Jonathan Moss
Assistants: Simon Bennett, Andy Halliday
Fourth official: Stuart Attwell