Manchester United midfielder Ander Herrera (hamstring) has been ruled out and none of Phil Jones, Marcos Rojo (both knocks), Marouane Fellaini and Zlatan Ibrahimovic (both knee) are ready to return.
Chelsea remain without David Luiz, Tiemoue Bakayoko and Ross Barkley (thigh) but have no new injury concerns.
Did you know?
Manchester United have won only one of their last 14 matches in all competitions against Chelsea (D5 L8), which was this fixture last season in the Premier League (2-0).
Chelsea are aiming to do the double over Man Utd for the fourth time in the Premier League and the first time since 2009/10 (also 2004/05 and 1993/94).
As Chelsea head coach Antonio Conte has won three of his four meetings in all competitions against Jose Mourinho (W3 L1).
Romelu Lukaku is still looking for his first goal in matches against the "Big Six" this season, managing only four shots on target in six such appearances.
Club previews
Man Utd: Mourinho on Herrera and Pogba latest
Chelsea: Conte: Ready to play as a team
Referee: Martin Atkinson
Assistants: Lee Betts, Simon Bennett
Fourth official: Andre Marriner
