Huddersfield Town's Collin Quaner (thigh), Chris Lowe (foot) and Martin Cranie (ankle) have been ruled out.
Philip Billing and Michael Hefele are improving their fitness in training, says David Wagner, and January signing Terence Kongolo is in contention.
West Ham United have doubts over Winston Reid, Andy Carroll and Michail Antonio.
James Collins, Aaron Cresswell, Marko Arnautovic and Manuel Lanzini are back in training but it is unknown if they are fit to play.
Did you know?
West Ham United won the reverse fixture 2-0 in September but have never before won both league matches against Huddersfield Town in any of the previous 15 seasons they’ve met.
Huddersfield Town are winless in their last four Premier League matches, with defeat at Leicester City last time out following a run of three successive draws.
West Ham have won five points from their last three PL away matches (W1 D2 L0), two more than they’d earned in their opening nine on the road this season (W0 D3 L6).
Marko Arnautovic has scored in his last two PL away appearances; only five players have ever scored in 3+ consecutive away PL matches for West Ham, most recently Diafra Sakho in October 2014.
What the managers say
David Wagner: "The West Ham away game (2-0) was one of the performances where I think we really underperformed. That's something that we would all together like to correct because we are better than what we showed there."
See: Wagner's press conference
David Moyes: "They can play, their style is good, and they play from the back at the right times. Their team is also confident and I think they come with momentum."
See: Moyes on Chicharito's role
Referee: Jonathan Moss
Assistants: Eddie Smart, Andy Halliday
Fourth official: Mike Dean