Arsenal's Mesut Ozil and Laurent Koscielny (Achilles) are both doubts for Wednesday's match at Emirates Stadium.
Sead Kolasinac (ankle) has been ruled out after limping off against West Bromwich Albion, joining Nacho Monreal, Olivier Giroud and Aaron Ramsey on the sidelines.
Chelsea are still without just two players, David Luiz (knee) and Charly Musonda (groin), whom Antonio Conte says could return in the FA Cup trip to Norwich City.
Did you know?
Arsenal will look to go unbeaten against Chelsea in a Premier League season for the first time since 2011/12 (W1 D1), while the last time they stopped them scoring was in 1998/99.
In all competitions, no team have won more away matches at Emirates Stadium than Chelsea's five (level with Manchester United).
What the managers say
Arsene Wenger: "Chelsea are coming back into good form. They've been consistent recently so it's a big challenge for us."
See: Wenger: Why we're under pressure
Antonio Conte: "It is very important in my plan to involve all my players, and we are doing a really good job in this situation because we are making many rotations but at the same time our results are positive."
See: Conte on the transfer window
Referee: Anthony Taylor
Assistants: Adam Nunn, Lee Betts
Fourth official: Craig Pawson
