Jose Mourinho says he is unable to give Romelu Lukaku a rest, with the striker set to start a 21st consecutive Premier League match for Manchester United.
Eric Bailly (ankle), Michael Carrick (other) and Marouane Fellaini (knee) remain unavailable and Chris Smalling (groin), Matteo Darmian (knock), Anthony Martial (knee) and Antonio Valencia (thigh) are not yet expected to return.
Southampton remain without first-choice full-backs Cedric Soares (ankle) and Ryan Bertrand (thigh), plus striker Charlie Austin (hamstring and suspended).
Did you know?
Manchester United have kept a clean sheet in each of their last three Premier League matches against Southampton, after a run of nine meetings without one.
Southampton have won two of their last three league visits to Old Trafford, after a run of 19 matches without a win there (D3 L16).
Man Utd have the chance to do the double over Southampton for the first time since 2012/13.
Zlatan Ibrahimovic has scored four goals in his two appearances against Southampton in all competitions.
What the managers say
Jose Mourinho: “We [played Lukaku and Ibrahimovic together] against Burnley and we will do that in some more matches if we need to do it, but I think for both of them to play together, we really need them to be at their best level.”
See: Mourinho on Lukaku fitness
Mauricio Pellegrino: "Man Utd is a powerful team, but we're in a moment where we have to think more about what we have to do.”
Referee: Craig Pawson
Assistants: Peter Kirkup, Richard West
Fourth official: Bobby Madley
