The Senegal winger suffered a hamstring injury while on international duty and could be unavailable for up to six weeks, Liverpool have confirmed on their official website.
If he is out for that long then Mane would miss four further Premier League fixtures.
|14/10/17||Man Utd (H)|
|04/11/17||West Ham (A)|
Mane scored in each of Liverpool's first three matches of the season and was named the EA SPORTS Player of the Season for August.
See: More on Mane injury