Stoke City are without captain Ryan Shawcross (back). Eric Maxim Choupo-Moting (hamstring) will be assessed.
Mark Hughes says a few players picked up injuries over the international break, with Kurt Zouma (ankle), Darren Fletcher and Mame Biram Diouf (both knee) all doubtful.
Manchester United manager Jose Mourinho still needs to assess his squad, but Zlatan Ibrahimovic and Marcos Rojo (both knee) are definitely out.
Did you know?
Stoke City are unbeaten in their last four home Premier League matches against Manchester United (W2 D2) since losing four of their first five between 2008 and 2013.
Mark Hughes is unbeaten in his last three PL meetings with Jose Mourinho (W1 D2 L0). Only Ronald Koeman has gone unbeaten in four or more against Mourinho (5) in the competition.
Henrikh Mkhitaryan has provided five assists in his first three PL matches this season. Only Thierry Henry (2004/05) and Cesc Fabregas (2014/15) have managed six from their first four matches.
Romelu Lukaku has scored 16 goals and assisted two more in his last 18 PL matches.
What the managers say
Mark Hughes: "We will give Man Utd the respect that they deserve, but sometimes the best way to do that is to get about them and ask questions."
See: Shawcross injury latest
Jose Mourinho: "They are aggressive, defend with a lot of people and are dangerous on the counter-attack."
See: Mourinho's team news update