Here's what to look out for over the next week, with eight clubs playing in Europe, and another big weekend of Premier League action ahead, concluding with Manchester City taking on Tottenham Hotspur.
Tuesday
In the Champions League, Man City host RB Leipzig and Newcastle United, who have lost their last two matches in Europe, travel to France for their match with Paris Saint-Germain.
If Newcastle are beaten in Group F, they will all but rule out their chances of getting into the knockout stages.
Man City need to avoid defeat to guarantee themselves as winners of Group G.
Both matches kick off at 20:00 GMT.
Arsenal manager Mikel Arteta and Man Utd boss Erik ten Hag will hold their respective press conferences ahead of Wednesday's Champions League matches.
A draw will guarantee Arsenal go through to the last-16, while a win will mean they top Group B.
Defeat in Istanbul will stop Man Utd progressing from Group A.
Wednesday
Arsenal host Lens and the Gunners will be hoping to avenge their 2-1 loss when the two last met, as will Man Utd when they face Galatasaray in Turkey, who beat the Red Devils 3-2 at Old Trafford in the second match of this season's competition.
Both fixtures kick off at 20:00 GMT.
Thursday
In the UEFA Europa League, Brighton & Hove Albion are away to AEK Athens, while West Ham United face Backa Topola, both encounters place at 17:45 GMT.
West Ham and Brighton are guaranteed a place in the next round with a win in Group A and Group B respectively.
Liverpool, who were beaten in Toulouse last time out in the competition, welcome LASK to Anfield at 20:00 GMT.
In the UEFA Europa Conference League, Aston Villa take on Legia Warsaw at 20:00 GMT, knowing they need just one more point from their final two matches to reach the knockout stages.
Several managers will also hold press conferences as they provide updates ahead of the weekend's Premier League fixtures.
Friday
The remaining Premier League managers will hold their press conferences, providing the latest team news.
Saturday
There are a bumper FIVE matches taking place, including three 15:00 GMT kick-offs, concluding with the 20:00 GMT match between Newcastle and Man Utd at St James' Park.
Sunday
The action continues with yet another FIVE fixtures, four starting at 14:00 GMT, including Chelsea against Brighton.
Matchweek 14's final match is between Man City and Spurs at the Etihad Stadium from 16:30 GMT.