Watford's Daryl Janmaat (groin) and Costel Pantilimon (ankle) will be assessed but Nordin Amrabat (ankle), Christian Kabasele (hip), Ben Watson (groin) and Mauro Zarate (knee) will certainly miss out.
Southampton have no fresh injury concerns following their EFL Cup final defeat to Manchester United, though long-term absentees such as Virgil van Dijk (ankle), Charlie Austin (shoulder) and Matt Targett (thigh) remain sidelined.
Watford have won one of their five Premier League matches against Southampton (W1 D2 L2).
The Hornets have scored only four goals in their previous PL meetings with Saints, failing to net in three of their last four matches.
Manolo Gabbiadini could become the first Saints player to score in his first three Premier League appearances for the club.
Troy Deeney has scored four goals in his last five Premier League appearances.
Walter Mazzarri: “We need to improve and stop sitting back. We have done it too many times, and it is a mentality we need to change."
Claude Puel: "After the first disappointment (v Man Utd) now we have satisfaction to see our performance, which showed the quality we can put out on the pitch. We have to keep that confidence for Watford.”