A measure of a player's ability to find the net, the Threat component of the Index places the Arsenal attacker out in front with a score of 1038.
Utilised as a central attacker until a recent shift onto the flank, Sanchez - who has already matched his 13-goal tally from 2015/16 - is also ranked first for shots inside the box (44) and efforts on target (28) among FPL midfielders.
Indeed, the Chilean is top overall for the ICT Index this season with a score of 264.5, having also created 54 scoring opportunities for team-mates.
Although he has scored only six goals compared to his team-mate's nine, Firmino has boasted a greater threat than Mane. He leads the Senegal international for total attempts (60 to 43), efforts in the penalty area (43 to 38) and shots on target, by 26 to 16.
West Ham United's Michail Antonio (£6.8m) and Arsenal wide man Theo Walcott (£7.5m) are neck and neck for goals (eight) and shots inside the box (39) so far this season, with only 10 Threat points separating the duo.
Antonio has been raiding the box more frequently over the last six Gameweeks; he is second only to Sanchez for penalty area attempts by 14 to 16 during that spell.
Owned by 10.3% of FPL managers, the Hammers winger faces home matches with Crystal Palace and West Bromwich Albion in the next five Gameweeks and also travels to Middlesbrough.
Subject to more transfers in than any player in the Gameweek, Alli has registered 10 big chances - or gilt-edged opportunities - to Eriksen's two.
He has netted double the number of goals, by 10 to five, scoring twice in each of his last three appearances.
Eriksen's total of 79 attempts on goal is more than any midfielder, while his tally of 27 efforts on target is second only to Sanchez.
But 21 of Eriksen’s attempts have come from set-piece situations, only West Ham's Dimitri Payet has produced more efforts (22) from dead-balls.
Ranked first for ICT Creativity this term, Payet is conspicuous by his absence in the ICT Threat top 10.
The Frenchman has scored from just two of 55 attempts on goal, converting a mere 3.6% of his opportunities - a far cry from last season, where 13% of his attempts found the back of the net.
Paul Pogba (£8.5m) is one of four midfielders - along with Sanchez, Firmino and Eriksen - to claim a place in the ICT Index top 10 for both Creativity and Threat.
Over the last six Gameweeks, Pogba's 11 efforts on target is top for midfielders, while he sits second for total attempts (27) over that spell.
The forthcoming schedule provides Pogba with a platform to go on building momentum as an FPL asset.
From Gameweek 22 onwards, four of Pogba's six opponents score two in the Fixture Difficulty Rankings.