Lying four points behind leaders Manchester City with two matches remaining, Liverpool need a victory at Southampton to keep their Premier League title hopes alive.
Man City's superior goal difference means that a draw at St Mary's would leave the Reds requiring an improbable combination of results on the final day to pip Pep Guardiola's men.
A Southampton win would result in City being crowned 2021/22 champions.
Find out the latest team news here.
Southampton won this exact fixture 1-0 last season. They last won consecutive home league matches against Liverpool between March 2004 and March 2013 (three in a row).
Liverpool have won eight of their last nine league matches against Southampton, scoring at least twice in each victory.
Liverpool have won seven of their eight midweek (Tuesday, Wednesday, Thursday) Premier League matches this season (L1). However, one of their two defeats overall in the competition this term came on a Tuesday (1-0 v Leicester).
Southampton’s eight Premier League home wins over Liverpool have been won by eight different managers (Branfoot, Ball, Strachan, Sturrock, Redknapp, Pochettino, Koeman and Hasenhuttl). The last Saints manager to win consecutive home league matches against Liverpool was Chris Nicholl, in 1989/90 and 1990/91.
Referee: Martin Atkinson. Assistants: Constantine Hatzidakis, Richard West. Fourth official: David Coote. VAR: Stuart Attwell. Assistant VAR: Adam Nunn.