Liverpool's Trent Alexander-Arnold (£7.5m) is an absolute must-have. He will not be as restricted with Virgil van Dijk (£6.5m), Joe Gomez (£5.0m) and Ibrahima Konate (£5.5m) providing strength in central defence.
The other premium defenders I like a lot are John Stones (£5.5m), who I believe is first-choice for Manchester City, the best defence in the country, and Everton’s Lucas Digne (£5.5m), who will likely be on set-pieces in an organised Rafa Benitez defence.
Alexander-Arnold is the standout premium defender pick because Van Dijk has returned to fitness and crowds are back at Anfield.
Two left-backs, Luke Shaw (£5.5m) and Digne, should also be considered. Both are key attacking outlets for their respective sides and also take a large number of set-pieces.
Alexander-Arnold is the clear winner here. He will likely have multiple 200+ point seasons over his Fantasy career and there's a good chance he can deliver his second in 2021/22.
The opening fixtures of the season make Digne very attractive, especially when you consider Matt Ritchie's (£5.0m) FPL returns under Benitez from a similar position for Newcastle United.
It also seems unthinkable not to have a Liverpool defender going into the season. Alexander-Arnold is my preferred pick, however Andrew Robertson (£7.0m) or Van Dijk could provide better value.
The best answer here is Alexander-Arnold, who will produce his usual attacking numbers and be a better bet for clean sheets with Van Dijk back to anchor the defence.
To provide some variety, I'll add Ben Chilwell (£6.0m), who could finish among the top five defenders if his minutes improve for Chelsea.
Alexander-Arnold is my go-to pick from the premium defenders. He has it all: goals, assists and clean sheets.
I also have my eye on Robertson on the opposite flank. He had more touches in the opposition box than any other defender last term and always seems to start the season strongly.
There's no question on this one. Alexander-Arnold offers unrivalled attacking potential coupled with clean sheets to match.
I'm considering the double-up with Robertson, expecting Liverpool to reclaim their defensive solidity.
Part 1: FPL experts: The best goalkeepers
Part 2: FPL experts: The best budget defenders
Part 4: FPL experts: The best budget midfielders
Part 5: FPL experts: The best premium midfielders
Part 6: FPL experts: The best budget forwards
Part 7: FPL experts: The best premium forwards
Part 8: FPL experts: The best differentials