Team news
Marcus Rashford (muscle) could be back for Manchester United, while Anthony Martial is due to have a scan on a hip injury sustained during Thursday's UEFA Champions League draw with AC Milan.
David De Gea has returned to England from Spain following the birth of his first child and is following quarantine protocol.
West Ham United report no fresh injury concerns, but on-loan midfielder Jesse Lingard is ineligible to face his parent club.
Angelo Ogbonna, Arthur Masuaku and Andriy Yarmolenko are still sidelined.
Did you know?
Man Utd can claim a Premier League double over West Ham for the first time since David Moyes was their manager in 2013/14.
Man Utd can keep four consecutive league clean sheets under Ole Gunnar Solskjaer for the first time.
West Ham can become the fourth London club to win at Man Utd this season, which would be a PL first.
As a visiting manager Moyes has never won a PL match at Old Trafford in 13 attempts.
Match officials
Referee: Martin Atkinson. Assistants: Gary Beswick, Sian Massey-Ellis. Fourth official: Craig Pawson. VAR: Jonathan Moss. Assistant VAR: Nick Hopton.