Team news
Dominic Calvert-Lewin and Allan are in contention for Everton, but Yerry Mina (calf) is ruled out.
Southampton's Oriol Romeu will miss the remainder of the season and undergo surgery on Monday on a fractured ankle.
Takumi Minamino (hamstring) is ruled out for Saints, who also have Ibra Diallo, Kyle Walker-Peters, Theo Walcott, Michael Obafemi and William Smallbone injured.
Did you know?
Everton are unbeaten in their last 15 home Premier League matches against Southampton (W10 D5), since losing losing 2-0 to them in 1997/98.
No side have scored more headed goals in the top flight than Everton this season. Exactly half of them have come from Dominic Calvert-Lewin, whose five headers are more than any other player this season.
Following their 2-0 victory against Everton in October, Southampton are looking to secure their first league double over the Toffees since 1997/98.
Saints striker Danny Ings has been directly involved in seven goals in his nine PL starts against Everton, producing five goals and two assists.
Match officials
Referee: Martin Atkinson. Assistants: Lee Betts, Eddie Smart. Fourth official: Darren England. VAR: Jonathan Moss. Assistant VAR: Marc Perry.