They may be the most successful team in Premier League history but in their 29th season Manchester United have the chance to achieve a feat they have never managed before when they visit Newcastle United on Saturday.
For more on this and all the must-know stats for Matchweek 5, read on. To check out the head-to-head records, click on the fixtures.
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Everton head into a top-flight Merseyside derby as the league leaders for the first time since 1989.
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Chelsea have won seven of their last eight home matches, scoring 18 goals and conceding only four.
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Manchester City have recorded six successive Premier League victories against Arsenal, scoring three goals in each of their last three top-flight encounters.
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Man Utd can achieve a club first with a sixth straight top-flight away win while scoring at least twice each time.
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Sheffield United have secured victory in each of their last 10 Premier League home matches against London sides.
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Wilfried Zaha has scored six goals against Brighton & Hove Albion, more than he has registered against any other team.
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Harry Kane has been involved in a competition-high nine goals this season, scoring three and setting up six.
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Aston Villa are looking to win their opening four league matches of a season for the first time since 1930/31.
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Burnley will try to avoid starting a top-flight campaign with four straight defeats for the first time since 1927/28.
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Leeds United are unbeaten in three matches, and are undefeated at home so far this season.
