Crystal Palace have lost their last five matches but can complete their first ever league double over Manchester United, having won 2-1 at Old Trafford in August.
Ole Gunnar Solskjaer's side are targeting a third straight away win, having triumphed 3-0 in the last two, as they chase a top-four finish.
Team news
Jeffrey Schlupp will return to the matchday squad for Palace while James Tomkins is back in training.
But the Eagles are without the suspended Christian Benteke.
Solskjaer revealed Mason Greenwood and Luke Shaw are doubts due to ankle injuries, but Brandon Williams (cut head) should be available.
Axel Tuanzebe and Phil Jones remain sidelined.
Did you know?
Palace have won seven of their nine Premier League matches in which Jordan Ayew has scored this season, drawing the other two. Their record when he doesn’t score is W4 D7 L15.
Roy Hodgson is seeking to avoid losing six consecutive Premier League matches for the first time since his last three with Blackburn Rovers in November 1998 and his first three with Fulham in January 2008.
Man Utd are unbeaten in their last 11 away league meetings with Palace (W8 D3), since a 3-0 defeat in May 1991.
Bruno Fernandes could become the first Man Utd player to score in five consecutive PL away matches since Zlatan Ibrahimovic in January 2017, and the fourth to do so overall, after Ruud van Nistelrooy (twice) and Robin van Persie.
Match officials
Referee: Graham Scott. Assistants: Harry Lennard, Derek Eaton. Fourth official: Keith Stroud. Replacement official: Garry Maskell. VAR: Simon Hooper. Assistant VAR: Andy Garratt.
