Southampton are targeting successive league wins, having triumphed 3-1 at Watford last time out.
Manchester City beat champions Liverpool 4-0 in their last match and have won 10 of their last 12 meetings with Saints.
Team news
Moussa Djenepo and Jack Stephens are back from suspension, but Pierre-Emile Hojbjerg and Sofiane Boufal are doubts.
Jannik Vestergaard (muscular), Yan Valery and Nathan Tella are all out.
Man City have reported no new injury concerns, suggesting only Sergio Aguero (knee) is unavailable.
Did you know?
Southampton’s Danny Ings has scored the opening goal in eight different Premier League matches this season, more than any other player.
Against Watford, James Ward-Prowse scored his sixth direct free-kick in the Premier League for Southampton. This has only been bettered by Matthew Le Tissier, who netted seven for the Saints.
Manchester City have not lost three consecutive away league matches since a run of four defeats on their travels in April 2015.
Since his Premier League debut for Man City in September 2015, Kevin De Bruyne has created more chances (432) and assisted more goals (62) than any other player.
Match officials
Referee: Andre Marriner. Assistants: Simon Long, Harry Lennard. Fourth official: Keith Stroud. Replacement official: Graham Kane. VAR: Andy Madley. Assistant VAR: Stephen Child.
