Wolverhampton Wanderers are seeking a fourth successive win which would take them above Chelsea in the table.
A third consecutive victory would move Arsenal within three points of their opponents and boost their chances of securing European football next season.
Wolves have no fresh injury concerns following their 1-0 win at Aston Villa.
Lucas Torreira is available for Arsenal, but Mesut Ozil (back) will be assessed.
Bernd Leno, Calum Chambers, Gabriel Martinelli (all knee) and Pablo Mari (ankle) remain sidelined for the Gunners.
Wolverhampton Wanderers are currently on a run of 405 minutes without conceding a Premier League goal since Serge Aurier netted against them for Tottenham Hotspur in March.
Wolves have scored a league-high 73 per cent of their Premier League goals this season in the second half, while also conceding a league-low 11 times after half-time.
Arsenal have won five of their last seven Premier League encounters (L2), one more than they managed in their previous 23 contests (W4 D13 L6).
Pierre-Emerick Aubameyang scored 22 Premier League goals in 2018/19 and needs one more this season to become only the second Gunners player to score 20 goals in consecutive campaigns, after Thierry Henry's five in a row between 2001/02 and 2005/06).
Referee: Michael Oliver. Assistants: Stuart Burt, Dan Cook. Fourth official: Andre Marriner. Replacement official: Craig Taylor. VAR: Paul Tierney. Assistant VAR: Lee Betts.