Burnley will look to bounce back from their 5-0 defeat at Manchester City with a win that could take them into the top half.
A victory for 16th-placed Watford would put more distance between themselves and the bottom three.
Sean Dyche will again be without Chris Wood (Achilles), Johann Berg Gudmundsson (calf), Ashley Barnes and Robbie Brady (both groin).
Watford full-backs Adam Masina (cramp) and Kiko Femenia (hamstring) will be assessed, although both players trained this week.
Burnley have won four of their seven Premier League matches against Watford and triumphed 3-0 earlier this season at Vicarage Road.
Having gone 19 Premier League encounters without a draw at Turf Moor (W9 L10), two of Burnley’s last three home league matches have ended level (W1).
Watford head coach Nigel Pearson has won his last three league trips to Burnley, with Leicester City in 2012/13, 2013/14 and 2014/15.
The Hornets are seeking back-to-back league wins at Burnley for the first time since April 2004, when they did so in the second tier.
Referee: Mike Dean. Assistants: Darren Cann, Nick Hopton. Fourth official: Peter Bankes. VAR: Martin Atkinson. Assistant VAR: Daniel Cook. Replacement official: Graeme Fyvie.