Everton are aiming to bounce back from their first Premier League defeat under Carlo Ancelotti at Manchester City in Matchweek 21.
Brighton & Hove Albion are two matches unbeaten and sit 14th and only a point behind their hosts.
Everton trio Alex Iwobi (hamstring), Jean-Philippe Gbamin (thigh) and Andre Gomes (ankle) all remain sidelined, but Gomes will start individual training next week as he steps up his rehabilitation following surgery.
Solly March is back in contention for Brighton after overcoming a groin injury, although Aaron Mooy is a doubt after getting a knock to his knee.
Dan Burn has joined long-term absentee Jose Izquierdo (knee) in the treatment room after breaking his collar bone.
The home side have never lost in the five PL meetings between Everton and Brighton (W4 D1). The Toffees have won both matches at Goodison Park and Brighton have never won at Everton in any competition (D2 L5).
Everton have kept nine clean sheets in their last 15 home Premier League matches (W9 D3 L3), recording a shutout in their last two.
Since Ancelotti’s first match, Everton's 50 shots are more than any other team. The Italian is set to face Brighton for the first time in the Premier League and has beaten 21 of the 22 teams he has come up against, only failing against his current club.
Brighton’s Alireza Jahanbakhsh has scored with his two shots on target in the Premier League this season, netting in his last two appearances. He could become the first Iranian to strike in three PL matches in a row.
Referee: David Coote. Assistants: Stuart Burt, Nick Hopton. Fourth official: Jonathan Moss. VAR: Michael Oliver. Assistant VAR: Scott Ledger.