Southampton are targeting a first home win of the season as they attempt to close the gap on 17th-placed West Ham United.
Bottom side Watford are seeking a second win in three matches to jump above Saints in the table.
Team news
Southampton's Stuart Armstrong will miss out after sustaining a hamstring problem against Arsenal, while Sofiane Boufal (toe) is unlikely to feature.
Jannik Vestergaard (illness) returned to training on Thursday and could be in contention.
Craig Dawson (head), Christian Kabasele (hamstring) and Daryl Janmaat (knee) are ruled out for Watford, as are Tom Cleverley (heel), Danny Welbeck (hamstring) and Sebastian Prodl (knee).
Roberto Pereyra and Daniel Bachmann (both hamstring) along with Domingos Quina (groin), all trained this week but Saturday's match may come too soon for the trio.
Did you know?
Southampton have won six of their last 11 top-flight home encounters against Watford, although they have failed to win any of the last three.
Shane Long scored after eight seconds in the 1-1 draw against Watford last season, making it the fastest goal in Premier League history.
The last three Premier League meetings with Southampton and Watford have finished level, with Watford coming from behind to draw on each occasion.
Watford are looking to win consecutive away league matches for the first time since winning their opening three on the road in 2017/18.
Match officials
Referee: Michael Oliver. Assistants: Stuart Burt, Simon Bennett. Fourth official: Graham Scott. VAR: Jarred Gillett. Assistant VAR: Andy Halliday.
