Chelsea are targeting a seventh win in eight Premier League matches with an immediate response to their defeat at Manchester City last time out.
West Ham United are aiming to end a seven match winless run that has taken Manuel Pellegrini's side to fourth from bottom, three points above the relegation zone.
Team news
Tammy Abraham has been ruled out after suffering a hip injury in Chelsea's UEFA Champions League draw against Valencia.
Frank Lampard reports no other fresh injury concerns for the Blues.
West Ham's Issa Diop is unavailable as he serves a one-match suspension.
Lukasz Fabianski, Manuel Lanzini, Jack Wilshere and Winston Reid remain sidelined, although the latter will return to full training next week.
Did you know?
Chelsea are unbeaten in their last 13 home Premier League meetings with West Ham (W9), last losing to the Hammers by a 3-2 scoreline in September 2002.
Michail Antonio has scored in each of his last three Premier League London derbies – no player has ever scored in four such successive appearances in the competition for West Ham.
No side have opened the scoring in more different Premier League matches this season than Chelsea, who have gone in front on 11 occasions. Five of those 11 goals have been netted by striker Tammy Abraham, who boasts the best record in the division.
West Ham have lost more Premier League derbies than any other side and defeat on Saturday would be their 100th in the competition (W67 D48 L99). Chelsea have won more derby matches (W128 D67 L54) and also have the best points-per-game ratio (1.8).
Match officials
Referee: Jonathan Moss. Assistants: Marc Perry, Eddie Smart. Fourth official: Stephen Martin. VAR: Andy Madley. Assistant VAR: Derek Eaton.
