Defender Cedric Soares is expected to start after missing the last four Premier League matches and Claude Puel also has hopes for Fraser Forster (abdominal), Dusan Tadic (broken nose), Ryan Bertrand and Pierre-Emile Hojbjerg (both knocks).
"I think we can recover many players," Claude Puel told southamptonfc.com. "I think it's okay for Fraser and Pierre. They have some injuries in the last week, but they should be fine.
"Ryan is okay and Tadic had an injury to his nose, but he spoke with the medical team already and should be fine for Saturday’s game."