Defour has been a key presence in Burnley's midfield but missed last week's draw with Manchester United to recover from a hamstring injury.
"A player's urge is to play, particularly in games like that," said Dyche.
"We had to make a judgement call with the medical team here and we decided it wasn't the right thing to do."
Alan Pardew has hailed the work of Dyche.
"He has done a super job at Burnley, two promotions at that football club tells its own story and he is a young manager who has done it the right way," the Palace manager told cpfc.co.uk.