Yakubu and Tim Cahill both netted twice as Everton ran riot in a 7-1 demolition of Sunderland at Goodison Park.
Yakubu's early strike on 12 minutes and Cahill's smart shot on the turn put Everton in charge. Steven Pienaar soon rifled in an excellent third goal before Dwight Yorke hit back for Sunderland on the stroke of half-time.
Cahill slid home another composed finish after the break before Yakubu made it five.
Substitute Andrew Johnson raced through to score the sixth, before Leon Osman's late solo effort completed an emphatic victory for David Moyes’s team.
"That was probably the best performance in my time here. Some of our football was fantastic and our passing and movement was just outstanding," Moyes said.
Nathaniel Clyne's late goal denied Aston Villa a precious victory at Villa Park.
Gabriel Agbonlahor put the home side ahead, pouncing on an error by Saints goalkeeper Fraser Forster, for the first goal conceded by second-placed Southampton in 439 minutes of football.
But Clyne, who had recently made his England debut, denied Villa all three points when he made it 1-1 from Ryan Bertrand's delivery.
The result stopped a sequence of three home defeats for Villa, who were winless since triumphing against Liverpool in mid-September.
The late point saw Southampton close the gap to Premier League leaders Chelsea to six points.