Tottenham Hotspur will secure a top-four finish as long as they avoid defeat and an eight-goal swing in goal difference with fifth-placed Arsenal, while they could overtake Chelsea and finish third.
Everton are seeking to hold on to eighth place, with Leicester City lying two points behind them.
Team news
Spurs will be without a trio of players this weekend. Jan Vertonghen sustained an ankle injury against Ajax and both Juan Foyth and Son Heung-Min are suspended.
Victor Wanyama (thigh) and Danny Rose (hamstring) are being assessed.
Harry Kane (ankle), Harry Winks (groin) and Davinson Sanchez (thigh) remain sidelined.
Dominic Calvert-Lewin is ruled out for Everton after picking up a knock in training this week. Richarlison (rib) is also sidelined while Seamus Coleman (groin) face a late test.
Did you know?
Spurs are unbeaten in their last 12 PL meetings with Everton (W7 D5) and have won the last four by an aggregate score of 16-4.
The north Londoners have won their final PL fixture in seven of the last eight seasons, while their last three such matches have produced a total of 23 goals after a 5-1 defeat against Newcastle United and 7-1 and 5-4 victories over Hull City and Leicester City respectively.
Christian Eriksen has scored in his last three PL appearances against Everton.
Everton have lost their final PL match in the last two campaigns, with both defeats coming in London against Arsenal and West Ham United.
Referee: Andre Marriner
Assistants: Scott Ledger, Simon Long
Fourth official: David Coote
