West Ham United, who lie 11th, are looking for a second consecutive victory after beating Tottenham Hotspur, with a top-half finish still within reach.
Southampton, who secured their Premier League status on Saturday after back-to-back draws, are aiming to end their season on a high.
Team news
West Ham manager Manuel Pellegrini reports that Andriy Yarmolenko (calf), Andy Carroll (ankle) and Winston Reid (knee) are the only injury absentees.
Samir Nasri, Aaron Cresswell and Manuel Lanzini could all return.
Southampton will be without Maya Yoshida (illness) and Jannik Vestergaard (muscle) but Mario Lemina and Stuart Armstrong are available.
Did you know?
None of the last 15 PL meetings between these sides in London have been drawn, with West Ham winning 11 to Southampton's four.
The Hammers, who won 2-1 at St Mary’s earlier this season, are looking to do the double over Southampton for the first time since 2000/01.
A different West Ham player has scored a brace in their last three PL matches against Southampton, with Chicharito, Marko Arnautovic and Felipe Anderson all doing so.
Southampton can score in a 10th successive PL match for the first time since December 2002, when Gordon Strachan was in charge.
Referee: Stuart Attwell
Assistants: Stephen Child, Constantine Hatzidakis
Fourth official: Martin Atkinson
