Eight teams will play twice in Double Gameweek 35, including six of the top 10 in the Premier League.
The Belgian also excelled against Spurs in the UEFA Champions League on Wednesday night, supplying three assists as City won 4-3 but were knocked out on aggregate.
De Bruyne takes his place in a 3-5-2 formation as The Scout goes all-in on Pep Guardiola’s title-challengers, with Raheem Sterling (£11.5m) handed the captain's armband and Sergio Aguero (£11.7m) given the vice-captaincy.
The Watford goalkeeper faces Huddersfield Town and Southampton, two of the bottom five teams in the Premier League. Foster has recorded at least one save point in 12 of his last 13 Gameweek appearances.
The Irishman’s 33 shots in the box and 15 shots on target are both more than any other defender. Wolverhampton Wanderers are the only team to play at home twice in Double Gameweek 35, hosting Brighton & Hove Albion and Arsenal.
The Frenchman has scored three goals, more than any other Arsenal defender, in his 13 Gameweek appearances. Koscielny has averaged 4.5 points per match ahead of his home meeting with Crystal Palace and trip to Wolves.
The budget Southampton centre-back offers all-round potential in away matches against Newcastle United and Watford. Yoshida has an assist, two clean sheets and four bonus points in his last six matches.
Six of his seven goals and four of his assists have arrived in home matches. Owned by just 6.9 per cent, Jota is an ideal differential for managers looking to make up ground in their mini-leagues.
Owned by 4.7 per cent, the Belgian offers managers a ready-made differential as Man City push for the title.
Having started every match since Gameweek 18, the Dane looks the most secure option in the Spurs attack to face Man City and Brighton. The in-form Eriksen has 26 FPL points in his last three appearances.
The Man City midfielder has seven goals and 59 FPL points in his last five Gameweek starts. Sterling also scored two goals against Spurs in the UEFA Champions League on Wednesday evening.
The Wolves striker is one of the standout contenders for the Gameweek 35 captaincy. Jimenez has three double-digit hauls in his last four home fixtures.
The Argentinian has five goals and two assists in his last seven Gameweek appearances. Owned by 37.8 per cent of managers, Aguero is the most popular player in FPL ahead of his pair of matches.
Holly Shand (@FFCommunity_): I like the Man City attacking triple-up for their crunch pair of games! Yoshida is a great budget option for those using their Bench Boost chip.
Ash (@FPLHints): The triple Man City attacking coverage makes perfect sense as their exit from Europe allows them to focus solely on winning the league. I'm unsure about Doherty and Yoshida in defence due to their lack of clean sheets.
Lee (@FPLFamily): I’m surprised by the Man City attack treble up. Their opponents are tough even though Spurs were awful in midweek defensively. I feel more at ease with treble Wolves, especially with two really nice home games.
Sam (@FPLFamily): De Bruyne ran the midweek UEFA Champions League fixture but Man City’s two fixtures make me question the inclusion of three of their attackers. I would like to see a Watford attacker in this selection due to their favourable matches.
Paul Gee (FPLPaulGee): Pogba is a surprise selection for me, it seems like a pick based on last week’s penalties. I would rather go with an Arsenal attacker.