Both sides are looking for a second successive victory and a larger gap above the relegation zone, after a win for 18th-placed Cardiff City on Tuesday night.
Newcastle United sit 15th, seven points clear of the bottom three, while Southampton are one place and two points below their hosts but have a match in hand.
Newcastle are only without long-term absentees Florian Lejeune, who underwent a successful knee operation this week, and Sean Longstaff (also knee).
Southampton's Mario Lemina (abdominal) is back in training, although this match may come too soon for him, while there are also doubts over Jannik Vestergaard (groin).
Alex McCarthy, Matt Targett and Charlie Austin have minor problems and face late fitness tests but Yan Valery (cramp) is fit to play. Michael Obafemi (hamstring) is in individual training.
Of Newcastle’s 10 PL victories this season, 70 per cent have come by a one-goal margin. Only Brighton & Hove Albion have won a higher percentage of their Premier League matches by a single goal.
Ayoze Perez has been involved in five goals in his last six PL home matches for Newcastle, scoring four and assisting another.
Southampton have only lost one of their last nine PL matches against Newcastle (W4 D4), although that defeat came in this fixture last season when they succumbed to a 3-0 reverse.
Saints are looking to secure consecutive PL away wins for the first time since March 2017, having won at Brighton in their last match on the road.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Kevin Friend