After starting March in fourth, Manchester United have slipped to sixth following two defeats in their last three matches.
West Ham will be looking to improve on a run of no wins in 19 PL away matches against top-six opposition.
Team news
Ashley Young and Luke Shaw are both suspended for Ole Gunnar Solskjaer, who is still without Ander Herrera. Fellow midfielder Nemanja Matic (illness) remains a doubt.
West Ham will be missing Andy Carroll, who has undergone ankle surgery, while Samir Nasri (calf) is a doubt. Jack Wilshere (ankle), Winston Reid (knee), Andriy Yarmolenko (Achilles) and Carlos Sanchez (knee) remain sidelined.
Did you know?
Man Utd are winless in their last four Premier League matches immediately following a European fixture, losing at Manchester City, Liverpool and Arsenal and drawing at Southampton.
Following their 3-1 victory at the London Stadium in September, West Ham are looking to complete the league double over the Red Devils for the first time since 2006/07.
Romelu Lukaku has scored six goals in his last five home PL matches against West Ham. Only four other players in the competition have netted in more successive home matches against a single opponent: Alan Shearer v Everton, Thierry Henry v Aston Villa, Jimmy Floyd Hasselbaink v West Ham (all six) and Sergio Aguero v Liverpool (seven).
West Ham have lost six of their last seven PL away matches, failing to score in each defeat.
Referee: Graham Scott
Assistants: Mick McDonough, Neil Davies
Fourth official: Michael Oliver
