Chelsea are aiming for a victory that would lift them into the top four, but they have been unable to beat West Ham United in the last three meetings.
Chelsea have reported no new injuries but head coach Maurizio Sarri says he will rotate his players to keep them fresh for the season run-in.
West Ham have been boosted by the return to training of Felipe Anderson, Samir Nasri and Ryan Fredericks.
Andy Carroll, Jack Wilshere (both ankle), Andriy Yarmolenko (leg), Carlos Sanchez and Winston Reid (both knee) are long-term absentees.
Chelsea have not lost a home Premier League match on a Monday since December 1994 (W11 D3).
Eden Hazard has been directly involved in nine goals in his last nine PL appearances at Stamford Bridge, with four strikes and five assists.
After a run of eight London derbies without a win (D5 L3), West Ham have won four of their last five in the Premier League (D1).
Hammers forward Chicharito could become the fifth player to score in five consecutive PL away matches against the same opponent, after Dion Dublin v Spurs, Alan Shearer v Leeds United, Ruud van Nistelrooy v Newcastle United and Robert Pires v Spurs.
Referee: Chris Kavanagh
Assistants: Daniel Cook, Constantine Hatzidakis
Fourth official: Jonathan Moss